#Coronavirus

Can The ‘Delta Plus’ Variant Escape Vaccines? An Expert Explains

Covaxin For Kids, COVID in fully vaccinated peopleThird COVID-19 Vaccine Dose, Johnson & Johnson’s Vaccine, Covid vaccine trial on children, viral shedding, comirnaty, Sanofi-GSK COVID-19 vaccine, COVID vaccine her immunity, Delta Plus Variant Escape Vaccines, Johnson and Johnson vaccine ,Johnson and Johnson vaccine ,Trials Of Covavax On Children, Janssen Vaccine, janssen-vaccine, Heart Inflammation Risk Warning, pfizer vaccine india ,Best COVID Vaccine, mRNA COVID-19 vaccine, Pfizer vaccine for children, Punjab Students Planning To Go Abroad ,vaccine free ,COVID-19 vaccine after effect Pfizer and BioNTech Vaccine For Children, COVID vaccine start working, Covaxin trials on children ,Two COVID-19 Vaccine Doses Same Day, Pfizer-BioNTech Vaccine For Adolescents, slot for COVID-19 vaccination ,Moderna Pfizer Turns Down States Vaccine,India-Pfizer ,vaccine for children ,Sputnik Light ,Delayed Second Pfizer COVID-19 Shot, Pfizer Vaccine, rare COVID vaccine side-effects, Biological E. Vaccine Candidate, valneva vaccine, woman hates needles , Pfizer Donates DrugsVaccination for pregnant women ,COVAXIN ,COVID-19 reinfection ,co-win ,vaccine registration ,COVID-19 Vaccine For Below 18 Years, Free COVID-19 Vaccination ,Covishield Vaccine Open Market Price, Free COVID-19 vaccine ,COVID19 Vaccination Phase 3 ,18 years above eligible ,Priority Vaccines For Journalists ,Sputnik V Vaccine ,anti-rabies vaccine ,double shots of covid-19 vaccine ,100-Year-Old Woman vaccinated ,Bollywood stars COVID-19 vaccine ,Germany suspends AstraZeneca, After effects of COVID-19 infection ,Oxford Vaccine Europe Ban, Johnson Vaccine
Can Delta plus variant escape vaccines? Last month, the Indian government detected a new mutation in the Delta coronavirus variant, prompting it to classify it as a variant of concern.

The Indian health ministry classifies a variant as one of concern as soon as there’s evidence for increased transmission.

The new variant, known as “Delta plus”, AY.1 or B.1.617.2.1, has an extra mutation in the spike protein of the SARS-CoV-2 virus, the virus that causes COVID-19.

This mutation was found in samples from 48 people infected with the Delta variant in India, out of more than 45,000 samples.

So how is this variant different, and can it escape vaccine protection?

Remind me, what’s the Delta variant?

The more infectious Delta variant of the coronavirus has spread across the globe and is on track to become the world’s dominant strain, according to the World Health Organization.

The variant has been the dominant strain that led to the crippling second wave in India.

Studies have found it can replicate faster, spread more easily, and bind more strongly to lung cell receptors.

Also, in a pre-print study yet to be peer-reviewed, Delhi researchers found the variant caused three-quarters of “breakthrough infections” in the city. These are infections in people who’ve been vaccinated. Around 8% of these breakthrough infections had the Kappa variant, and 76 percent had the Delta variant.

How is the ‘plus’ variant different?

The new mutation in the Delta variant was first detected in Europe in March.

In June, COVID patients in India were also found to have the mutant virus. These developments have raised concerns.

Some scientists in India fear the mutation may fuel another wave of infections in the country.

The mutation in the spike protein of the virus, however, is not new. Known as “K417N”, it has been previously reported in the Beta variant first found in South Africa. The Beta variant with this mutation has shown an ability to escape the antibodies conferred by COVID vaccination, at least to some extent. In other words, there’s the possibility COVID vaccines will not protect against this mutation so effectively.

Will vaccines work against Delta plus?

According to the Indian health ministry, Delta plus could have a similar ability to evade immunity and an ability to reduce the effect of monoclonal antibody therapies used to treat COVID.

The mutation is worrying because it’s located on a key portion of the virus, the spike protein, used to penetrate human cells.

Previous mutations have been on the “receptor binding domain” of the spike protein that allows the virus to attach to the receptors in our cells.

The unique mutations in the Delta variant mean the virus can escape the immune system to some extent. Indeed, Delta has shown to reduce efficacy of vaccines somewhat. This means a single dose of vaccine may offer reduced protection.

 Delta Plus Variant Escape Vaccines, Zydus Cadila vaccine, COVID-19 Vaccination Infertility ,Vaccine for sex workers in Kolkata ,Man injected Empty Syringe ,Best COVID vaccine, covid-19 vaccines for women, COVID vaccine start working, COVID vaccine tourism, COVID vaccination in diabetes, valneva vaccine, woman hates needles, how to register on cowin, Covishield fights double mutant, What is Vaccination, Johnson Vaccine, Double Mutations ,COVID Vaccine After Coronavirus Infection, Vaccination for people above 45, blood clots from covishield, COVID vaccine for pregnant women, Novavax claims vaccine to be 90 per cent effective ,Pfizer effective on UK strain, sero-prevalence, abantika ghosh

Image credit: Unsplash

However, a second dose has been shown to produce enough antibodies against symptomatic infection and severe disease. It’s important to remember most COVID vaccines don’t provide absolute sterilising immunity, but work to reduce the severity of disease.

UK researchers found the Pfizer vaccine had an efficacy of 33 percent against Delta after a single shot, and 88 percent after both doses. In the case of the AstraZeneca vaccine, the efficacy was just 33 percent after the first dose but went up to 60 percent after the second dose.

The Delta plus variant might have a similar degree of reduction in efficacy against the vaccines currently in use. Though we’re yet see good data on whether this is the case.

Studies are under way in India to assess the effectiveness of vaccines against Delta plus.

It’s important to note Delta plus hasn’t yet taken off substantially, and the World Health Organization hasn’t yet classified it as a variant of concern.

What do we need to do now?

Variants with increased transmissibility and the potential to escape antibodies pose a threat to efforts to control and mitigate the pandemic. And countries with low vaccination rates may see new outbreaks.

How should our response change? Despite the mutations, no extra special measures need to be taken. We must continue to get maximum numbers of people vaccinated, increase genomic surveillance to track the evolution of the virus, and follow COVID-appropriate behaviour.

Sunit K Singh, Professor of Molecular Immunology and Virology, Institute of Medical Sciences, Banaras Hindu University published this article first on The Conversation. The views expressed are the author’s own.